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Brasesquilignan A-E, Five New Furofurans Lignans from Selaginella braunii Baker.

ABSTRACT: Five new furofurans lignans, Brasesquilignan A-E (1-5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds 2 and 3 exhibited weak inhibitorypotency against five human cancer cells.

SUBMITTER: Cheng F

PROVIDER: S-EPMC9572557 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Brasesquilignan A-E, Five New Furofurans Lignans from Selaginella braunii Baker.

Cheng Fei F Wu Jianping J Zhang Yan Y Wang Yuyan Y Li Guihua G Zeng Hongliang H He Xiaoai X Deng Guiming G Tan Jianbin J Long Hongping H Zeng Puhua P Liu Yiheng Y Zhu Gangzhi G Chen Zuhui Z Xu Kangping K

Molecules (Basel, Switzerland) 20220926 19

Five new furofurans lignans, Brasesquilignan A-E (1-5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds 2 and 3 exhibited weak inhi ...[more]

PMID: 36234885

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