Unknown

Dataset Information

0

Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity.

ABSTRACT: Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the cell death of various cancer cell lines. In the current paper, we have demonstrated a new method for synthesis of LPAs via the multicomponent Ugi reaction and subsequent reduction of amide groups by PhSiH3. The anticancer activity of the obtained compounds was evaluated in the A-549, MCF7, and HCT116 cancer cell lines. For the first time, it was shown that the anticancer activity of LPAs with piperazine fragments is comparable with that of aliphatic LPAs. The presence of a diglyceride fragment in the structure of LPAs appears to be a key factor for the manifestation of high anticancer activity. The findings of the study strongly support further research in the field of LPAs and their derivatives.

SUBMITTER: Nichugovskiy A 

PROVIDER: S-EPMC9572921 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity.

Nichugovskiy Artemiy A   Maksimova Varvara V   Trapeznikova Ekaterina E   Eshtukova-Shcheglova Elizaveta E   Ivanov Igor I   Yakubovskaya Marianna M   Kirsanov Kirill K   Cheshkov Dmitry D   Tron Gian Cesare GC   Maslov Mikhail M  

Molecules (Basel, Switzerland) 20220921 19

Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the cell death of various cancer cell lines. In the current paper, we have demonstrated a new method for synthesis of LPAs via the multicomponent Ugi reaction and subsequent reduction of amide groups by PhSiH<sub>3</sub>. The anticancer activity of the obtained compounds was evaluated in the A-549, MCF7, and HCT116 cancer cell lines. For the f  ...[more]

Similar Datasets

Unknown Synthesis of novel lipophilic N-substituted norcantharimide derivatives and evaluation of their anticancer activities.
| S-EPMC6271113 | biostudies-literature
Unknown An intramolecular hydrogen bond-promoted "green" Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity.
| S-EPMC9678023 | biostudies-literature
Unknown Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.
| S-EPMC5813278 | biostudies-literature
Unknown The sustainable synthesis of peptidomimetics <i>via</i> chemoenzymatic tandem oxidation-Ugi reaction.
| S-EPMC9084175 | biostudies-literature
Unknown A Facile Ugi/Ullmann Cascade Reaction to Access Fused Indazolo-Quinoxaline Derivatives with Potent Anticancer Activity.
| S-EPMC10820152 | biostudies-literature
Unknown Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction.
| S-EPMC6042644 | biostudies-literature
Unknown Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity.
| S-EPMC6409784 | biostudies-literature
Unknown Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.
| S-EPMC3170163 | biostudies-literature
Unknown Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction.
| S-EPMC6278549 | biostudies-literature
Unknown Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction.
| S-EPMC2917892 | biostudies-literature