Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper.

ABSTRACT: Data on alkaloid interactions with the physiologically important transition metals, iron and copper, are mostly lacking in the literature. However, these interactions can have important consequences in the treatment of both Alzheimer's disease and cancer. As isoquinoline alkaloids include galanthamine, an approved drug for Alzheimer's disease, as well as some potentially useful compounds with cytostatic potential, 28 members from this category of alkaloids were selected for a complex screening of interactions with iron and copper at four pathophysiologically relevant pH and in non-buffered conditions (dimethyl sulfoxide) by spectrophotometric methods in vitro. With the exception of the salts, all the alkaloids were able to chelate ferrous and ferric ions in non-buffered conditions, but onl

SUBMITTER: Parvin MS 

PROVIDER: S-EPMC9572997 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature