Anti-Ovarian Cancer Conotoxins Identified from Conus Venom.

ABSTRACT: Conotoxins constitute a treasury of drug resources and have attracted widespread attention. In order to explore biological candidates from the marine cone snail, we isolated and identified three novel conopeptides named as Vi14b, Vi002, Vi003, three conotoxin variants named as Mr3d.1, Mr3e.1, Tx3a.1, and three known conotoxins (Vi15a, Mr3.8 and TCP) from crude venoms of Conus virgo, Conus marmoreus and Conus texile. Mr3.8 (I-V, II-VI, III-IV) and Tx3a.1 (I-III, II-VI, IV-V) both showed a novel pattern of disulfide connectivity, different from that previously established for the µ- and ψ-conotoxins. Concerning the effect on voltage-gated sodium channels, Mr3e.1, Mr3.8, Tx3a.1, TCP inhibited Na_v1.4 or Na_v1.8 by 21.51~24.32% of currents at semi-activ

SUBMITTER: Ju S 

PROVIDER: S-EPMC9573077 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature