Circulating Levels of Short-Chain Fatty Acids during Pregnancy and Infant Neurodevelopment.

ABSTRACT:

Background

Short-chain fatty acids (SCFA) play a key role in the gut microbiota-brain crosstalk regulating the main neurodevelopmental processes during pregnancy. The aim of this study is to investigate the longitudinal relationship between prenatal levels of the main SCFAs in maternal serum and infant cognitive development and temperament on day 40 postpartum after adjusting for several pre-, peri- and post-natal confounders.

Methods

A sample of 357 healthy mother-infant pairs were followed from the beginning of pregnancy to 40 days after birth. Serum SCFA concentrations were assessed in the first and third trimester of pregnancy by LC-MS/MS; and socio-demographic, nutritional, and psychological variables were collected. At 40 days, the Bayley Scales of Infant Development-I

SUBMITTER: Hernandez-Martinez C 

PROVIDER: S-EPMC9573109 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature