From cis-Lobeline to trans-Lobeline: Study on the Pharmacodynamics and Isomerization Factors.

ABSTRACT: Lobeline is an alkaloid derived from the leaves of an Indian tobacco plant (Lobelia inflata), which has been prepared by chemical synthesis. It is classified as a partial nicotinic agonist and has a long history of therapeutic usage ranging from emetic and respiratory stimulant to tobacco smoking cessation agent. The presence of both cis and trans isomers in lobeline is well known, and many studies on the relationship between the structure and pharmacological activity of lobeline and its analogs have been reported. However, it is a remarkable fact that no studies have reported the differences in pharmacological activities between the two isomers. In this article, we found that different degrees of isomerization of lobeline injection have significant differences in resp

SUBMITTER: Xu HH 

PROVIDER: S-EPMC9573392 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature