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Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation.

ABSTRACT: This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondialdehyde; (2) preventing liver inflammation by suppressing NF-κB pathway and reducing proinflammatory cytokines secretion (e.g., tumor necrosis factor-α, interleukin-1β, and interleukin-6); (3) inhibiting liver fibrosis and collagen deposition by regulating the expression of transforming growth factor-β and α-smooth muscle actin; (4) modulating abnormal bile acid metabolism through increasing the expression of bile salt export pump and multidrug resistance-associated protein 2. This study was the first to elucidate the potential preventive effect of RCM extracts on DDC-induced cholestasis in mice from multiple pathways, which suggested that RCM fruits could be considered as a potential dietary supplement to prevent cholestasis.

SUBMITTER: Sun Y

PROVIDER: S-EPMC9573408 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Protective Effect of <i>Rhus chinensis</i> Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation.

Sun Yilin Y Cai Shengbao S Zhang Yuanyue Y Ma Nan N Yi Junjie J Hu Xiaosong X Wang Tao T

Nutrients 20221001 19

This study focused on the preventive effects of the extracts of <i>Rhus chinensis</i> Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondia ...[more]

PMID: 36235742

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Project description:In the present study, silver nanoparticles were synthesized using aqueous root and leaf extracts of Rhus chinensis Mill. This study aimed to undertake the green synthesis of silver nanoparticles utilizing plant extracts in an eco-friendly, cost-effective, and more efficient manner with its antibacterial application. The prepared silver nanoparticles (AgNPs) were characterized by using different techniques. Such as ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction spectroscopy (XRD), field emission-scanning electron microscopy (FE-SEM), and energy dispersive X-ray (EDX). The color changes from yellowish to reddish brown can be visualized and it indicates the formation of silver nanoparticles. The UV-Vis absorption peak shown by the synthesized AgNPs assisted by root and leaf extract was at 443 nm and 440 nm respectively. The functional group present in plants' secondary metabolites may act as capping and stabilizing agents, indicated by the shifting and disappearing of the peak in the plant extracts and the extracts-assisted synthetic nanoparticles. The crystallite size of synthesized AgNPs assisted by the root and leaf extracts of Rhus cinensis was found to be 11.01 nm and 13.39 nm respectively, while with the help of FE-SEM image the shape and particle size of synthesized AgNPs root and leaf extract was found spherical with particle diameter of 54.40 nm and 30.89 nm respectively. The presence of an intense silver component was confirmed by EDX analysis which showed an intense peak at around 3 Kev and other elements like Cl, O, C, and N were also reported in synthesized AgNPs. Both the plant extracts assisted synthesized AgNPs showed higher zones of inhibition (ZOI) against both the Gram-positive and Gram-negative bacteria. The results of the study indicate the potential benefit of synthesized silver nanoparticles using Rhus chinensis root and leaf extracts for biomedical purposes.

Dataset Information

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation.

Publications

Protective Effect of <i>Rhus chinensis</i> Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation.

Similar Datasets

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