Ontology highlight
ABSTRACT:
SUBMITTER: Duro C
PROVIDER: S-EPMC9573586 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Duró Cintia C Jernei Tamás T Szekeres Krisztina J KJ Láng Győző G GG Oláh-Szabó Rita R Bősze Szilvia S Szabó Ildikó I Hudecz Ferenc F Csámpai Antal A
Molecules (Basel, Switzerland) 20221010 19
Utilizing McMurry reactions of 4,4'-dihydroxybenzophenone with appropriate carbonyl compounds, a series of 4-Hydroxytamoxifen analogues were synthesized. Their cytotoxic activity was evaluated in vitro on four human malignant cell lines (MCF-7, MDA-MB 231, A2058, HT-29). It was found that some of these novel Tamoxifen analogues show marked cytotoxicity in a dose-dependent manner. The relative ROS-generating capability of the synthetized analogues was evaluated by cyclic voltammetry (CV) and DFT ...[more]