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A Novel Utilization of Water Extract of Suaeda Salsa in the Pd/C Catalyzed Suzuki-Miyaura Coupling Reaction.

ABSTRACT: Using biomass-derived solvents in various organic reactions is challenging for the fine chemicals industry. We herein report a Pd/C catalyzed Suzuki-Miyaura reaction in water extract of suaeda salsa (WES) without using external phosphine ligand, base, and organic solvent. The cross-coupling reactions were carried out in a basic WES medium with a broad substrate scope and wide functional group tolerance. Furthermore, the high purity of solid biaryl products can be obtained by column chromatography or filtration.

SUBMITTER: Ren C

PROVIDER: S-EPMC9573658 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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A Novel Utilization of Water Extract of Suaeda Salsa in the Pd/C Catalyzed Suzuki-Miyaura Coupling Reaction.

Ren Changyue C Zhang Hang H Chen Zhengjun Z Gao Jie J Yang Mingyan M Yuan Zeli Z Li Xinmin X

Molecules (Basel, Switzerland) 20221006 19

Using biomass-derived solvents in various organic reactions is challenging for the fine chemicals industry. We herein report a Pd/C catalyzed Suzuki-Miyaura reaction in water extract of suaeda salsa (WES) without using external phosphine ligand, base, and organic solvent. The cross-coupling reactions were carried out in a basic WES medium with a broad substrate scope and wide functional group tolerance. Furthermore, the high purity of solid biaryl products can be obtained by column chromatograph ...[more]

PMID: 36235160

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