Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds.

ABSTRACT: The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH₃, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as partition coefficient in system 1-octanol/buffer pH 7.4. The aqueous solubility of these chemicals is poor and ranged from 0.67 × 10^-4 to 1.98 × 10^-3 mol·L^-1. The compounds studied are more soluble in the buffer pH 2.0, simulating the gastrointestinal tract environment (by an order of magnitude) than in the buffer pH 7.4 modelling plasma of blood. The solubility in 1-octanol is significantly higher; that is because of the specific interactions of the compounds with the solvent. The pr

SUBMITTER: Sharapova A 

PROVIDER: S-EPMC9573696 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature