C. elegans toxicant responses vary among genetically diverse individuals.

ABSTRACT: The genetic variability of toxicant responses among indisviduals in humans and mammalian models requires practically untenable sample sizes to create comprehensive chemical hazard risk evaluations. To address this need, tractable model systems enable reproducible and efficient experimental workflows to collect high-replication measurements of exposure cohorts. Caenorhabditis elegans is a premier toxicology model that has revolutionized our understanding of cellular responses to environmental pollutants and boasts robust genomic resources and high levels of genetic variation across the species. In this study, we performed dose-response analysis across 23 environmental toxicants using eight C. elegans strains representative of species-wide genetic diversity. We observed substantial variation

SUBMITTER: Widmayer SJ 

PROVIDER: S-EPMC9573778 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature