Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells.

ABSTRACT: Aging results in enhanced myelopoiesis, which is associated with an increased prevalence of myeloid leukemias and the production of myeloid-derived suppressor cells (MDSCs). Tristetraprolin (TTP) is an RNA binding protein that regulates immune-related cytokines and chemokines by destabilizing target mRNAs. As TTP expression is known to decrease with age in myeloid cells, we used TTP-deficient (TTPKO) mice to model aged mice to study TTP regulation in age-related myelopoiesis. Both TTPKO and myeloid-specific TTPKO (cTTPKO) mice had significant increases in both MDSC subpopulations M-MDSCs (CD11b⁺Ly6C^hiLy6G^-) and PMN-MDSCs (CD11b⁺Ly6C^loLy6G⁺), as well as macrophages (CD11b⁺F4/80⁺) in the spleen and mesent

SUBMITTER: Kwack KH 

PROVIDER: S-EPMC9573970 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature