Expression pattern and clinical value of Key RNA methylation modification regulators in ischemic stroke.

ABSTRACT: Ischemic stroke (IS) is one of the major causes of death and disability worldwide, and effective diagnosis and treatment methods are lacking. RNA methylation, a common epigenetic modification, plays an important role in disease progression. However, little is known about the role of RNA methylation modification in the regulation of IS. The aim of this study was to investigate RNA methylation modification patterns and immune infiltration characteristics in IS through bioinformatics analysis. We downloaded gene expression profiles of control and IS model rat brain tissues from the Gene Expression Omnibus database. IS profiles were divided into two subtypes based on RNA methylation regulators, and functional enrichment analyses were conducted to determine the differentially expressed genes (D

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9574037 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature