Ontology highlight
ABSTRACT:
SUBMITTER: Bie L
PROVIDER: S-EPMC9574071 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Bie Lihua L Wang Yue Y Jiang Fuze F Xiao Zhen Z Zhang Lianjun L Wang Jing J
Frontiers in molecular biosciences 20221003
AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin overexpressed in cancer cells, however, little is known about their binding process. This study proposed a feasible binding mode for the first time and provided atomic-level descriptions for the high affinity and specific binding of AS1411. The binding pose predicted by docking was screened using knowledge-based criteria, and a microsecond molecular dynamics (MD) simulation showed the stable existence of the ...[more]