The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma.

ABSTRACT: Neuroblastoma is believed to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme, but instead become locked in a pro-proliferative developmental state. Achaete-scute homolog 1 (ASCL1) is a proneural master regulator of transcription which modulates both proliferation and differentiation of sympathetic neuroblast precursor cells during development, while its expression has been implicated in the maintenance of an oncogenic programme in MYCN-amplified neuroblastoma. However, the role of ASCL1 expression in neuroblastoma is not clear, especially as its levels vary considerably in different neuroblastoma cell lines. Here, we have investigated the role of ASCL1 in maintaining proliferation and controlling differentiation in both MYCN amplified

SUBMITTER: Parkinson LM 

PROVIDER: S-EPMC9574099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature