Atopy as an independent predictor for long-term patient and graft survival after kidney transplantation.

ABSTRACT:

Background

Atopy is a genetic condition predisposing individuals to develop immunoglobulin E (IgE) against common allergens through T-helper 2 (Th2) polarization mechanisms. The impact of atopy on graft survival in solid organ transplantation is unknown.

Methodology

We analyzed 268 renal allograft recipients from the Swiss Transplant Cohort Study, a prospective multicenter cohort studying patients after solid organ transplantation, with a 9-year median follow-up (IQR 3.0). We used the Phadiatop assay to measure IgE antibodies against a mixture of common inhaled allergens (grass, tree, herbs, spores, animals, and mites) to identify pre-transplantation atopic patients (>0.35 KU/L).

Results

Of 268 kidney transplant recipients, 66 individuals were atopic (24.6%). Atopic p

SUBMITTER: Porret R 

PROVIDER: S-EPMC9574189 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature