Clinical Features of Patients with Alzheimer's Disease and a History of Traumatic Brain Injury.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer's disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms (NPSs) in AD patients.

Methods

Biomarker-proven AD patients (CSF or amyloid PET) were selected from the Amsterdam Dementia Cohort. TBI events were classified by age at injury (TBI <25 or ≥25 years) and TBI severity (loss of consciousness, multiple events). Cognitive composite scores were calculated from results of a neuropsychological test battery. NPSs were assessed with th

SUBMITTER: van Amerongen S 

PROVIDER: S-EPMC9574209 | biostudies-literature | 2022 May-Aug

REPOSITORIES: biostudies-literature