Identification of potential drug targets for vascular dementia and carotid plaques by analyzing underlying molecular signatures shared by them.

ABSTRACT:

Background

Vascular dementia (VaD) and carotid atherosclerotic plaques are common in the elderly population, conferring a heavy burden on families and society. Accumulating evidence indicates carotid atherosclerotic plaques to be a risk factor for VaD. However, the underlying mechanisms for this association are mainly unknown.

Materials and methods

We analyzed temporal cortex gene expression data of the GSE122063 dataset and gene expression data of the GSE163154 dataset to identify commonly differentially expressed genes (DEGs). Then we performed functional enrichment analysis, immune cell infiltration and evaluation, correlation analysis between differentially expressed immune-related genes (DEIRGs) and immune cells, receiver operating characteristic (ROC) analysis, and dru

SUBMITTER: Shu J 

PROVIDER: S-EPMC9574221 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature