A randomized trial predicting response to cognitive rehabilitation in multiple sclerosis: Is there a window of opportunity?

ABSTRACT:

Background

Cognitive training elicits mild-to-moderate improvements in cognitive functioning in people with multiple sclerosis (PwMS), although response heterogeneity limits overall effectiveness.

Objective

To identify patient characteristics associated with response and non-response to cognitive training.

Methods

Eighty-two PwMS were randomized into a 7-week attention training (n = 58, age = 48.4 ± 10.2 years) or a waiting-list control group (n = 24, age = 48.5 ± 9.4 years). Structural and functional magnetic resonance imaging (MRI) was obtained at baseline and post-intervention. Twenty-one healthy controls (HCs, age = 50.27 ± 10.15 years) were included at baseline. Responders were defined with a reliable change index of 1.64 on at least 2/6 cognitive d

SUBMITTER: Prouskas SE 

PROVIDER: S-EPMC9574229 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature