Ontology highlight
ABSTRACT:
SUBMITTER: Zhao L
PROVIDER: S-EPMC9574346 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Zhao Lili L Zhang Yuhan Y Li Ang A Lu Xuebo X Li Mingzhu M Yuan Qiang Q Yang Ning N Zhao Xiaokun X Li Xin X Jiang Yanan Y Liu Kangdong K
Molecular therapy oncolytics 20220926
Epidemiological and mechanistic studies suggest that some US Food and Drug Administration (FDA)-approved drugs can reduce the incidence of cancer and inhibit tumor growth. Therefore, investigating FDA-approved drugs for cancer chemoprevention is a promising strategy. In this study, we screened FDA-approved drugs and found that azelnidipine, a Ca channel blocker widely used in the treatment of hypertension, inhibits the growth of esophageal squamous cell carcinoma (ESCC) <i>in vitro</i> and <i>in ...[more]