The endoplasmic reticulum membrane protein Sec62 as potential therapeutic target in SEC62 overexpressing tumors.

ABSTRACT: The human SEC62 gene is located on chromosome 3q, was characterized as a tumor driver gene and is found to be overexpressed in an ever-growing number of tumors, particularly those with 3q26 amplification. Where analyzed, SEC62 overexpression was associated with poor prognosis. Sec62 protein is a membrane protein of the endoplasmic reticulum (ER) and has functions in endoplasmic reticulum protein import, endoplasmic reticulum-phagy and -in cooperation with the cytosolic protein calmodulin- the maintenance of cellular calcium homeostasis. Various human tumors show SEC62 overexpression in immunohistochemistry and corresponding cell lines confirm this phenomenon in western blots and immunofluorescence. Furthermore, these tumor cells are characterized by increased stress to

SUBMITTER: Zimmermann JSM 

PROVIDER: S-EPMC9574383 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature