The prognostic value and molecular properties of tertiary lymphoid structures in oesophageal squamous cell carcinoma.

ABSTRACT:

Background

Tertiary lymphoid structures (TLSs) play key roles in tumour adaptive immunity. However, the prognostic value and molecular properties of TLSs in oesophageal squamous cell carcinoma (ESCC) patients have not been studied.

Methods

The prognostic values of the presence and maturation status of tumour-associated TLSs were determined in 394 and 256 ESCC patients from Sun Yat-sen University Cancer Center (Centre A) and the Cancer Hospital of Shantou University Medical College (Centre B), respectively. A deep-learning (DL) TLS classifier was established with haematoxylin and eosin (H&E)-stained slides using an inception-resnet-v2 neural network. Digital spatial profiling was performed to determine the cellular and molecular properties of TLSs in ESCC tissues.

Results<

SUBMITTER: Ling Y 

PROVIDER: S-EPMC9574489 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature