Still rocking in the structural era: A molecular overview of the small multidrug resistance (SMR) transporter family.

ABSTRACT: The small multidrug resistance (SMR) family is composed of widespread microbial membrane proteins that fulfill different transport functions. Four functional SMR subtypes have been identified, which variously transport the small, charged metabolite guanidinium, bulky hydrophobic drugs and antiseptics, polyamines, and glycolipids across the membrane bilayer. The transporters possess a minimalist architecture, with ∼100-residue subunits that require assembly into homodimers or heterodimers for transport. In part because of their simple construction, the SMRs are a tractable system for biochemical and biophysical analysis. Studies of SMR transporters over the last 25 years have yielded deep insights for diverse fields, including membrane protein topology and evolution, mechanisms of membrane

SUBMITTER: Burata OE 

PROVIDER: S-EPMC9574504 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature