Platelet-derived concentrates influence human keratinocyte proliferation in vitro and induce wound healing in a prospective case series of chronic wounds of different entities in vivo.

ABSTRACT:

Objectives

Soft tissues defects can extend into the fat layer or even deeper and can cause significant clinical disadvantages like pain, infections, and loss of function. In particular, chronic wounds are difficult to treat, as split-thickness skin grafts (STSGs) have varying success rates. To improve wound healing in chronic wounds, the authors have studied the application of platelet-mediator concentrate (PMC) in a human keratinocyte culture model in vitro and of autologous platelet concentrates (PRP) in a combination with surgical procedures in vivo as second line therapy in patients with initially failed wound closure.

Methods

For in vitro testing on keratinocytes, a PMC was processed with a commercially available bedside system (ATR^®, Cur

SUBMITTER: Paulmann A 

PROVIDER: S-EPMC9574654 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature