Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy.

ABSTRACT:

Purpose

To identify optic nerve (ON) lipid alterations associated with sonication-induced traumatic optic neuropathy (TON).

Design

Experimental study.

Subjects

A mouse model of indirect TON was generated using sound energy concentrated focally at the entrance of the optic canal using a laboratory sonifier with a microtip probe.

Methods

Analyses of datasets generated from high-performance liquid chromatography-electrospray tandem mass spectrometry of ONs dissected from the head of the ON to the optic chiasm at 1 day, 7 days, and 14 days postsonication compared with that in nonsonicated controls.

Main outcome measures

Lipid abundance alterations in postsonicated ONs were evaluated using 1-way analysis of variance (false discovery rate-adjusted significant

SUBMITTER: Chauhan MZ 

PROVIDER: S-EPMC9574713 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature