Impact of left atrial appendage fibrosis on atrial fibrillation in patients following coronary bypass surgery.

ABSTRACT:

Objectives

We aimed to assess the relationship of left atrial appendage (LAA) fibrosis with atrial fibrillation (AF) and postoperative events in patients receiving coronary artery bypass graft surgery (CABG).

Background

Increased atrial fibrosis has been associated with AF and worse outcome following catheter ablation. Only limited data exists focusing on the impact of LAA fibrosis on AF after CABG.

Methods

LAA tissue from 164 CABG-patients was stained with Masson-Goldner trichrome. The histological landscape was scanned and segmented into superpixels for software analysis (QuPath). A classification algorithm was extensively trained to detect fibrotic superpixels for quantification. In 43 propensity score matched pairs with AF or sinus rhythm (SR), LAA fibrosis was co

SUBMITTER: Eckstein J 

PROVIDER: S-EPMC9574744 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature