Influence of intensive lipid-lowering on CT derived fractional flow reserve in patients with stable chest pain: Rationale and design of the FLOWPROMOTE study.

ABSTRACT:

Introduction

Coronary CT angiography (CTA) derived fractional flow reserve (FFR_CT ) shows high diagnostic performance when compared to invasively measured FFR. Presence and extent of low attenuation plaque density have been shown to be associated with abnormal physiology by measured FFR. Moreover, it is well established that statin therapy reduces the rate of plaque progression and results in morphology alterations underlying atherosclerosis. However, the interplay between lipid lowering treatment, plaque regression, and the coronary physiology has not previously been investigated.

Aim

To test whether lipid lowering therapy is associated with significant improvement in FFR_CT , and whether there is a dose-response relationship between lipid lowering inte

SUBMITTER: Mortensen MB 

PROVIDER: S-EPMC9574753 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature