Evaluation of benefits and harms of adaptive screening schedules for lung cancer: A microsimulation study.

ABSTRACT:

Background

Although lung cancer screening (LCS) has been proven effective in reducing lung cancer mortality, it is associated with some potential harms, such as false positives and invasive follow-up procedures. Determining the time to next screen based on individual risk could reduce harms while maintaining health gains. Here, we evaluate the benefits and harms of LCS strategies with adaptive schedules, and compare these with those from non-adaptive strategies.

Methods

We extended the Lee and Zelen risk threshold method to select screening schedules based on individual's lung cancer risk and life expectancy (adaptive schedules). We compared the health benefits and harms of these adaptive schedules with regular (non-adaptive) schedules (annual, biennial and triennial) using

SUBMITTER: Cao P 

PROVIDER: S-EPMC9574899 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature