Time-varying connectivity of the precuneus and its association with cognition and depressive symptoms in neuromyelitis optica: A pilot MRI study.

ABSTRACT:

Background

The precuneus is involved in cognition and depression; static functional connectivity (SFC) abnormalities of this region have been observed in neuromyelitis optica spectrum disorders (NMOSD). Time-varying functional connectivity (TVC) underpins dynamic variations of brain connectivity.

Objective

The aim of this study was to explore precuneus SFC and TVC in NMOSD patients and their associations with neuropsychological features.

Methods

This retrospective study includes 27 NMOSD patients and 30 matched healthy controls undergoing resting state functional magnetic resonance imaging (MRI) and a neuropsychological evaluation of cognitive performance and depressive symptoms. A sliding-window correlation analysis using bilateral precuneus as seed region assessed T

SUBMITTER: Cacciaguerra L 

PROVIDER: S-EPMC9574904 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature