Larynx proteomics after jellyfish collagen IL: Increased ECM/collagen and suppressed inflammation

ABSTRACT: Abstract

Objectives/Hypothesis

Compare proteomic profiles of rabbit vocal folds (VFs) injected with micronized cross‐linked jellyfish collagen “collagen Type 0” (MX‐JC) against two clinical products for injection medialization laryngoplasty (IL).

Study Design

Animal model.

Methods

Left recurrent laryngeal nerve sectioning and IL were performed in New Zealand White rabbits (N = 6/group). Group 1 received (MX‐JC) and adipose‐derived stem cells (ADSCs), Group 2, MX‐JC alone; Group 3, cross‐linked hyaluronic acid; and Group 4, micronized acellular dermis. Animals were sacrificed at 4 and 12 weeks. Proteomic profiling of injected versus noninjected VFs by nano‐liquid chromatography, tandem mass spectrometry, and reactome gene ontology analysis was performed.

Resul

SUBMITTER: Bowen A 

PROVIDER: S-EPMC9575076 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature