The limits of molecular signatures for pancreatic ductal adenocarcinoma subtyping.

ABSTRACT: Molecular signatures have been suggested as biomarkers to classify pancreatic ductal adenocarcinoma (PDAC) into two, three, four or five subtypes. Since the robustness of existing signatures is controversial, we performed a systematic evaluation of four established signatures for PDAC stratification across nine publicly available datasets. Clustering revealed inconsistency of subtypes across independent datasets and in some cases a different number of PDAC subgroups than in the original study, casting doubt on the actual number of existing subtypes. Next, we built sixteen classification models to investigate the ability of the signatures for tumor subtype prediction. The overall classification performance ranged from ∼35% to ∼90% accuracy, suggesting instability of the signatures. Notably,

SUBMITTER: Lautizi M 

PROVIDER: S-EPMC9575186 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature