Genetic susceptibility of bladder cancer in the Lebanese population.

ABSTRACT:

Background

Bladder cancer (BC) is the 10^th most frequent tumor worldwide. Evidence shows an association between elevated risk of BC and various single nucleotide polymorphisms (SNP). BC incidence was the highest in Lebanon according to Globocan 2018 report, but little is known about the genetic susceptibility of Lebanese people to this disease. We aim to evaluate whether this prominent incidence of BC in Lebanon is attributable to known coding genetic variants.

Methods

A case-control study was conducted at Hotel-Dieu de France Hospital, Beirut. A cohort of 51 Lebanese patients with BC were recruited between 2017 and 2020. Whole Exome Sequencing (WES) was performed on peripheral blood samples to detect coding genetic variants in the patients. An in-house database i

SUBMITTER: Kourie HR 

PROVIDER: S-EPMC9575197 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature