Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice

ABSTRACT:

Background

Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protective role of hydrogen (H2), a gaseous molecule without known toxicity, in LPS-induced lung injury in mice and explored its potential molecular mechanisms.

Methods

Mice were randomly divided into three groups: H2 control group, LPS group, and LPS + H2 group. The mice were euthanized at the indicated time points, and the specimens were collected. The 72 h survival rates, cytokines contents, pathological changes, expression of Toll-like receptor 4 (TLR4), and oxidative stress indicators were analyzed. Moreover, under different culture conditions, RAW 264.7 mous

SUBMITTER: Yin H 

PROVIDER: S-EPMC9575233 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature