Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis.

ABSTRACT:

Background

The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence making it a potential therapeutic target. In addition, antibiotic treatment has been shown to ameliorate disease in the EAE mouse model of multiple sclerosis. Yet, to this date, the mechanisms mediating these antibiotic effects are not understood. Furthermore, there is no consensus on the gut-derived bacterial strains that drive neuroinflammation in multiple sclerosis.

Results

Here, we characterized the gut microbiome of untreated and vancomycin-treated EAE mice over time to identify bacteria with

SUBMITTER: Bianchimano P 

PROVIDER: S-EPMC9575236 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature