Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa.

ABSTRACT:

Background

Retinitis pigmentosa (RP) is a hereditary retinal disease which leads to visual impairment. The onset and progression of RP has physiological consequences that affects the ocular environment. Some of the key non-genetic factors which hasten the retinal degeneration in RP include oxidative stress, hypoxia and ocular inflammation. In this study, we investigated the status of the ocular immune privilege during retinal degeneration and the effect of ocular immune changes on the peripheral immune system in RP. We assessed the peripheral blood mononuclear cell stimulation by retinal antigens and their immune response status in RP patients. Subsequently, we examined alterations in ocular immune privilege machineries which may contribute to ocular inflammation and disease progre

SUBMITTER: Mohan KV 

PROVIDER: S-EPMC9575261 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature