Tau interactome and RNA binding proteins in neurodegenerative diseases.

ABSTRACT: Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology, conformation, and isoform ratio present in tau aggregates varies widely. The tau-mediated disease mechanisms that drive neurodegenerative disease are still unknown. Tau interactome studies are critically important for understanding tauopathy. They reveal the interacting partners that define disease pathways, and the tau interactions present in neuropathological aggregates provide potential insight into the cellular environment and protein interactions present during pathological tau aggregation. Here we provide a combined analysis of 12 tau interact

SUBMITTER: Kavanagh T 

PROVIDER: S-EPMC9575286 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature