Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target.

ABSTRACT:

Background

Improper use of strychnine can cause death. The aim of this study was to identify and evaluate toxic mechanisms of action associated with active compounds in strychnine using a network toxicology approach, and explore potential pathogenic targets.

Methods

In the present study, strychnine target and central nervous system-related gene set were established using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and four disease gene databases (Genecards, OMIM, PharmGkb, TTD). An "ingredient-target" interactive active network map was constructed using Cytoscape software (version 3.8.0). Functional enrichment analysis was performed based on the hub genes. A protein-protein interaction network was constructed using STRING database. The pharmacokine

SUBMITTER: Dai J 

PROVIDER: S-EPMC9575290 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature