Depression and fatigue in active IBD from a microbiome perspective-a Bayesian approach to faecal metagenomics.

ABSTRACT:

Background

Extraintestinal symptoms are common in inflammatory bowel diseases (IBD) and include depression and fatigue. These are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis. The aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active IBD.

Methods

We included clinical data of 62 prospectively enrolled patients with IBD in an active disease state. Patients supplied stool samples and completed the questionnaires regarding depression and fatigue symptoms. Based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used Bayesian statistics to

SUBMITTER: Thomann AK 

PROVIDER: S-EPMC9575298 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature