Microarray data reveal potential genes that regulate triple-negative breast cancer.

ABSTRACT:

Objective

Triple-negative breast cancer (TNBC) is characterized by a lack of targeted therapies and poor patient prognosis, and its underlying pathological mechanisms remain unclear. This study aimed to identify potential key genes and related pathways that are required for TNBC development.

Methods

We screened the Gene Expression Omnibus database for transcriptome data and identified differently expressed genes in TNBC. Then, we performed Gene Ontology analysis to determine the genes and pathways involved in TNBC development. We correlated significantly expressed genes and miRNAs using miRDB, TargetScan, miRWalk, and DIANA, and then validated the expression of CDK1 and miR-143-3p in TNBC patients.

Results

Eighteen genes were significantly upregulated in TNBC patients

SUBMITTER: Pan C 

PROVIDER: S-EPMC9575453 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature