Continuous infusion of piperacillin-tazobactam significantly improves target attainment in children with cancer and fever.

ABSTRACT:

Background

Children with febrile neutropenia commonly exhibit alterations of pharmacokinetic (PK) parameters, leading to decreased β-lactam concentrations.

Aims

This study evaluated piperacillin PK and probability of target attainment (PTA) with continuous infusion of piperacillin-tazobactam, in order to optimize the dosing regimen.

Methods

This prospective PK study included children with cancer, aged 1-17 years, who were treated with piperacillin-tazobactam for suspected or verified infection. A piperacillin-tazobactam loading dose (100 mg/kg) was administered followed by continuous infusion (300 mg/kg/day). The unbound fraction of piperacillin was quantified by high-performance liquid chromatography and PK were described using population PK modeling. PK data was use

SUBMITTER: Maarbjerg SF 

PROVIDER: S-EPMC9575485 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature