Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, and often involves invasion and distant metastasis from the early tumor stages. Myosin II reportedly plays a key role in regulating tumor progression and metastasis.

Aims

We examined whether myosin regulatory light polypeptide 9 (MYL9) regulates cancer cell proliferation.

Methods and results

To investigate the expression pattern and clinical significance of MYL9 in pancreatic ductal adenocarcinoma, we performed immunohistochemical analysis of samples collected from 101 patients with pancreatic ductal adenocarcinoma. The expression of MYL9 was investigated to evaluate its functional role and contribution to proliferation and apoptosis in pancreatic ductal adenocarcinoma cells in vit

SUBMITTER: Matsushita K 

PROVIDER: S-EPMC9575502 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature