Health-related quality of life in patients with multiple system atrophy using the EQ-5D-5L.

ABSTRACT:

Background

Multiple system atrophy (MSA) is an incurable neurodegenerative disease. We aimed to investigate the health-related quality of life (HRQoL) and the determinants of HRQoL in patients with MSA.

Methods

The five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) was used to evaluate patients' HRQoL. The results of HRQoL were indicated by the EQ-5D-5L index values and visual analog scale (EQ VAS) scores. Specific scales were used to measure disease severity, cognition, frontal lobe function, anxiety, depression, fatigue, and sleep disorders. The beta mixture model and the linear regression model were used to explore the determinants of HRQoL in patients with MSA.

Results

A total of 205 patients with cerebellar variants (MSA-C; 53.9%) and 175 patients with

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC9575615 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature