Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus.

ABSTRACT: The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a putative therapeutic target in diverse viral infections. However, directly targeting the LD lipolytic catabolism in virus-infected cells has not been widely investigated. Here, we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids (FFAs) at the late stage of diverse RNA viral infections, which represents a broad-spectrum antiviral target. Dysfunction of membrane transporter systems due to virus-induced cell injury results in intracellular malnutrition at the late stage of infection, thereby making the virus more dependent on the FFAs generated from LD storage for viral morphogenesis and as a source of energy. The replication of SA

SUBMITTER: Baek YB 

PROVIDER: S-EPMC9575645 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature