Systemic therapy for early-stage breast cancer: learning from the past to build the future

ABSTRACT: The treatment of breast cancer has improved dramatically over the past century, from a strictly surgical approach to a coordinated one, including local and systemic therapies. Systemic therapies for early-stage disease were initially tested against observation or placebo only in adjuvant trials. Subsequent clinical trials focusing on treatment ‘fine-tuning’ had a marked increase in cohort size, duration and costs, leading to a growing interest in the neoadjuvant setting in the past decade. Neoadjuvant trial designs have the advantages of enabling the direct evaluation of treatment effects on tumour diameter and offer unique translational research opportunities through the comparative analysis of tumour biology before, during and after treatment. Current technologies enabling the identifica

SUBMITTER: Agostinetto E 

PROVIDER: S-EPMC9575647 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature