Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors.

ABSTRACT: The serotonin system modulates a wide variety of emotional behaviors and states, including reward processing, anxiety, and social interaction. To reveal the underlying patterns of neural activity, we visualized serotonergic neurons in the dorsal raphe nucleus (DRN^5-HT) of mice using miniaturized microscopy during diverse emotional behaviors. We discovered ensembles of cells with highly correlated activity and found that DRN^5-HT neurons are preferentially recruited by emotionally salient stimuli as opposed to neutral stimuli. Individual DRN^5-HT neurons responded to diverse combinations of salient stimuli, with some preference for valence and sensory modality. Anatomically defined subpopulations projecting to either a reward-related structure (the ventral teg

SUBMITTER: Paquelet GE 

PROVIDER: S-EPMC9575686 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature