Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells.

ABSTRACT: The polycomb complex component Bmi1 promotes the maintenance of stem cells in multiple postnatal tissues, partly by negatively regulating the expression of p16^Ink4a and p19^Arf, tumor suppressors associated with cellular senescence. However, deficiency for p16^Ink4a and p19^Arf only partially rescues the function of Bmi1-deficient stem cells. We conditionally deleted Bmi1 from adult hematopoietic cells and found that this slowly depleted hematopoietic stem cells (HSCs). Rather than inducing senescence, Bmi1 deficiency increased HSC division. The increased cell division was caused partly by increased Aristaless-related homeobox (ARX) transcription factor expression, which also increased ribosomal RNA expression. However, <

SUBMITTER: Burgess RJ 

PROVIDER: S-EPMC9575696 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature