Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome.

ABSTRACT:

Objective

The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome.

Methods

A total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The g

SUBMITTER: Vicente ALSA 

PROVIDER: S-EPMC9575905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature