Biomarkers of maternal lead exposure during pregnancy using micro-spatial child deciduous dentine measurements.

ABSTRACT:

Background

Lead is a toxic chemical of public health concern, however limited biomarkers are able to reconstruct prior lead exposures in early-life when biospecimens are not collected and stored. Although child tooth dentine measurements accurately assess past child perinatal lead exposure, it has not been established if they reflect maternal exposure in pregnancy.

Aim

To assess the prenatal relationship between child tooth dentine and maternal blood lead measurements and to estimate maternal lead exposure during the 2nd and 3rd trimesters of pregnancy from weekly child dentine profiles.

Methods

We measured early-life lead exposure in child tooth dentine and maternal blood from 419 child-mother dyads enrolled in the Programming Research in Obesity, Growth, Environment

SUBMITTER: Gerbi L 

PROVIDER: S-EPMC9576006 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature