Glucagon receptor signaling at white adipose tissue does not regulate lipolysis.

ABSTRACT: Although the physiological role of glucagon receptor signaling in the liver is well defined, the impact of glucagon receptor (Gcgr) signaling on white adipose tissue (WAT) continues to be debated. Although numerous studies propose that glucagon stimulates WAT lipolysis, we lack evidence that physiological concentrations of glucagon regulate WAT lipolysis. In turn, we performed studies in both wild-type and WAT Gcgr knockout mice to determine if glucagon regulates lipolysis at WAT in the mouse. We assessed the effects of fasting and acute exogenous glucagon administration in wild-type C57BL/6J and Gcgr^Adipocyte+/+ versus Gcgr^Adipocyte-/- mice. Using an ex vivo lipolysis protocol, we further examined the direct effects of glucagon on physiologically

SUBMITTER: Vasileva A 

PROVIDER: S-EPMC9576180 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature