Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunity.

ABSTRACT:

Background

In the face of rapid emerging variants of concern (VOCs) with potential of evading immunity from Beta to Omicron and uneven distribution of different vaccine brands, a mix-match strategy has been considered to enhance immunity. However, whether increasing immunogenicity using such a mix-match can lead to high clinical efficacy, particularly when facing Omicron pandemic, still remains elusive without using the traditional phase 3 trial. The aim of this study is to demonstrate how to evaluate correlates of protection (CoP) of the mix-match vaccination.

Methods

Data on neutralizing antibody (NtAb) titers and clinical efficacy against Wuhan or D614G strains of homologous ChAdOx1 nCov-19 or mRNA-1273 and heterologous vaccination were extracted from previous studies for

SUBMITTER: Liao SH 

PROVIDER: S-EPMC9576222 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature